Shi Zhengli and her team discovered a new coronavirus in bats, named HKU5-CoV-2, with the potential to infect humans like SARS-CoV-2. Their study highlights the risk of spillover from HKU5-CoV-2 to humans through direct transmission or intermediary hosts. Researchers observed that HKU5-CoV-2 effectively adapts to the human ACE2 receptor, suggesting a greater threat compared to its predecessor.